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Toshiaki Makino Selected Research

Kampo Medicine (Kampo)

6/2022Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients.
1/2022Shin'iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines.
12/2021Application of Kampo medicines for the palliation of cancer cachexia.
3/2021Exploration for the real causative agents of licorice-induced pseudoaldosteronism.
1/2021A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study).
7/2020Suppressive Effects of Hainosan (Painongsan) against Biofilm Production by Streptococcus mutans.
9/2019Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.
1/201918β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism.
10/2018Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.
6/2018Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet.
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Toshiaki Makino Research Topics

Disease

8Liddle Syndrome
03/2021 - 07/2008
7Neoplasms (Cancer)
01/2022 - 12/2009
6Glomerulonephritis
01/2011 - 12/2002
5Sinusitis
01/2022 - 07/2016
5Infections
01/2021 - 08/2018
5Hypersensitivity (Allergy)
09/2017 - 03/2003
4Peripheral Nervous System Diseases (PNS Diseases)
01/2022 - 01/2014
4Hyperalgesia
09/2020 - 01/2014
3Allergic Rhinitis
01/2022 - 04/2004
3Neuralgia (Stump Neuralgia)
09/2020 - 06/2016
3Dermatitis
07/2014 - 06/2007
3Proteinuria
01/2005 - 03/2003
2Interstitial Lung Diseases (Interstitial Lung Disease)
01/2021 - 07/2008
2Hypertension (High Blood Pressure)
01/2021 - 11/2019
2Fever (Fevers)
01/2021 - 10/2015
2Liver Diseases (Liver Disease)
01/2021 - 04/2018
2Constipation
01/2021 - 10/2015
2Pain (Aches)
09/2019 - 06/2016
2Gout
11/2018 - 01/2014
2Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2018 - 03/2018
2Obesity
06/2018 - 03/2018
2Asthma (Bronchial Asthma)
05/2014 - 01/2010
1Lymphoma (Lymphomas)
06/2022
1Muscular Atrophy (Muscle Atrophy)
06/2022
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022
1Cachexia
12/2021
1Cough
01/2021
1Hypesthesia (Numbness)
01/2021
1Inflammation (Inflammations)
01/2021
1Virus Diseases (Viral Diseases)
01/2021
1Shock
01/2021
1Exanthema (Rash)
01/2021
1Edema (Dropsy)
01/2021
1Dyspnea (Shortness of Breath)
01/2021
1COVID-19
01/2021
1Multiple Myeloma
01/2021
1Hypoalbuminemia
01/2021
1Bacterial Infections (Bacterial Infection)
08/2020
1Gingivitis
07/2020
1Neutropenia
01/2020
1Aplastic Anemia (Anemia, Hypoplastic)
01/2020

Drug/Important Bio-Agent (IBA)

11Pharmaceutical PreparationsIBA
06/2022 - 10/2004
6Oxaliplatin (Eloxatin)FDA LinkGeneric
09/2020 - 01/2014
5Anti-Allergic Agents (Antiallergic Agents)IBA
01/2022 - 04/2005
5Glycyrrhizic Acid (Glycyrrhizin)IBA
01/2021 - 07/2008
4Anti-Bacterial Agents (Antibiotics)IBA
08/2020 - 01/2017
4Glycyrrhetinic Acid (Po 12)IBA
01/2019 - 07/2008
4PlatinumIBA
10/2017 - 01/2014
3OvalbuminIBA
01/2022 - 07/2014
3CytokinesIBA
01/2022 - 01/2018
3Proteins (Proteins, Gene)FDA Link
12/2021 - 01/2011
3Oxidoreductases (Dehydrogenase)IBA
03/2021 - 08/2012
3neolineIBA
09/2020 - 06/2016
3AntigensIBA
07/2016 - 11/2008
3AcidsIBA
07/2015 - 08/2012
2Paclitaxel (Taxol)FDA LinkGeneric
01/2022 - 09/2019
2Organic Anion TransportersIBA
03/2021 - 08/2012
2bu-zhong-yi-qi-tangIBA
01/2021 - 08/2018
2Adrenal Cortex Hormones (Corticosteroids)IBA
11/2019 - 01/2014
2PotassiumIBA
11/2019 - 01/2014
2Biomarkers (Surrogate Marker)IBA
11/2019 - 10/2018
2MineralsIBA
11/2019 - 01/2014
2bofu-tsusho-sanIBA
06/2018 - 03/2018
2sho-seiryu-toIBA
09/2017 - 05/2014
2AcetoneIBA
06/2016 - 01/2014
2HaptensIBA
07/2014 - 03/2009
2FibrinIBA
01/2011 - 10/2004
2Immunoglobulin E (IgE)IBA
03/2009 - 06/2007
2sairei-toIBA
01/2005 - 09/2004
2Superoxide DismutaseIBA
01/2005 - 09/2004
2shosaiko-to (TJ9)IBA
01/2005 - 09/2004
2Factor V (Coagulation Factor V)IBA
10/2004 - 10/2004
1Messenger RNA (mRNA)IBA
06/2022
1F-Box ProteinsIBA
06/2022
1TroponinIBA
06/2022
1branched-chain-amino-acid transaminaseIBA
06/2022
1Dexamethasone (Maxidex)FDA LinkGeneric
06/2022
1higenamine (norcoclaurine)IBA
06/2022
1Immunosuppressive Agents (Immunosuppressants)IBA
01/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1TabletsIBA
01/2021
1BilirubinIBA
01/2021
1periplocinIBA
01/2021
1Streptozocin (Streptozotocin)FDA Link
09/2020
1gosha-jinki-ganIBA
09/2020
1NAV1.7 Voltage-Gated Sodium ChannelIBA
09/2020
1Shiga Toxin (Shigella Toxin)IBA
08/2020
1lonicerae flosIBA
08/2020
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
01/2020
1IsomaltoseIBA
01/2020
1Therapeutic UsesIBA
01/2020

Therapy/Procedure

21Kampo Medicine (Kampo)
06/2022 - 07/2008
8Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2022 - 04/2004
5Therapeutics
12/2021 - 11/2003
2Drug Therapy (Chemotherapy)
01/2020 - 01/2014
2Subcutaneous Injections
09/2019 - 06/2016
2Traditional Medicine (Folk Remedies)
11/2018 - 10/2004
2saiboku-to
01/2005 - 09/2004
1Artificial Respiration (Mechanical Ventilation)
01/2021
1Oral Administration
01/2021